Dose-Finding Based on Bivariate Efficacy-Toxicity Outcome Using Archimedean Copula
نویسندگان
چکیده
منابع مشابه
Dose-Finding Based on Bivariate Efficacy-Toxicity Outcome Using Archimedean Copula
In dose-finding clinical study, it is common that multiple endpoints are of interest. For instance, efficacy and toxicity endpoints are both primary in clinical trials. In this article, we propose a joint model for correlated efficacy-toxicity outcome constructed with Archimedean Copula, and extend the continual reassessment method (CRM) to a bivariate trial design in which the optimal dose for...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0078805